Per-Operative Levosimendan Use In High-Risk Patients Undergoing Coronary Artery Bypass Surgery Yüksek Riskle Koroner Arter Cerrahisi Uygulanan Hastalarda Per-Operatif Levosimendan Kullanımı
نویسندگان
چکیده
1 Istanbul University, Institute of Cardiology, Department of Cardiovascular Surgery 2 Istanbul University, Institute of Cardiology, Department of Cardiology 3 Istanbul University, Institute of Cardiology, Department of Anesthesiology and Reanimation Aim: Although conventional inotropic drugs are well examined for myocardial support during weaning from cardiopulmonary bypass (CPB), there is limited experience about a new calcium sensitiser drug, levosimendan. We aimed to investigate effects of early infusion of ‘levosimendan’ started per-operatively without a loading dose, on outcomes of patients experiencing difficultly to wean from CPB after coronary artery bypass grafting (CABG).
منابع مشابه
eComment. Levosimendan in adult patients undergoing cardiac surgery.
[1] Toller W, Algotsson L, Guarracino F, Hormann C, Knotzer J, Lehmann A et al. Perioperative use of levosimendan: Best practice in operative settings. J Cardiothorac Vasc Anesth 2013;27:361–366. [2] Kivikko M, Antila S, Eha J, Lehtonen L, Pentikainen PJ. Pharmacodynamics and safety of a new calcium sensitizer, levosimendan, and its metabolites during an extended infusion in patients with sever...
متن کاملPreoperative levosimendan decreases mortality and the development of low cardiac output in high-risk patients with severe left ventricular dysfunction undergoing coronary artery bypass grafting with cardiopulmonary bypass.
BACKGROUND The calcium sensitizer levosimendan has been used in cardiac surgery for the treatment of postoperative low cardiac output syndrome (LCOS) and difficult weaning from cardiopulmonary bypass (CPB). OBJECTIVES To evaluate the effects of preoperative treatment with levosimendan on 30-day mortality, the risk of developing LCOS and the requirement for inotropes, vasopressors and intra-ao...
متن کاملThe Effectiveness of Levosimendan in Clinical Characteristics and Haemodynamic, in Patients Undergoing High-Risk Cardiac Surgery: A Systematic Review of Randomized, Clinical Trials
Aim: to evaluate the haemodynamic effects, perioperative and post-operative clinical characteristics of Levosimendan in in patients undergoing high-risk cardiac surgery. Methods: The review of the literature was based on a keyword strategy and pre-determined inclusion and exclusion criteria. The citation and reference list of the eligible articles were also screened for potentially relevant art...
متن کاملPretreatment with levosimendan improves outcome in off-pump coronary artery bypass grafting
Methods Loading dose of levosimendan at low-dose (12 mcg/kg), high-dose (24 mcg/kg) or placebo were administered in thirty-one patients in randomized controlled study. Bolus thermodilution by pulmonary artery catheter used for cardiac output (CO) measuring. Numerical data were described by median. To compare the three independent groups (low or high-dose levosimendan or placebo) the Kruskal-Wal...
متن کاملLevosimendan following coronary artery bypass grafting in a patient with end-stage renal failure: a case report.
Levosimendan is a novel inotropic agent indicated for patients with decompensated heart failure. It has well recognised mechanisms of action. Its use however, has not been described in patients with end-stage renal failure. This report describes the use of levosimendan in a post-operative coronary artery bypass graft patient with decompensated heart failure and end-stage renal failure previousl...
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تاریخ انتشار 2014